Structure of PDB 6ro1 Chain A Binding Site BS01

Receptor Information

>6ro1 Chain A (length=919) Species: 9606 (Homo sapiens)

LADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILD
AFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPI
KALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSE
VMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQ
FAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFRED
NFNTAMQVLRDAGDLAKKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEA
YALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRG
IGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNA
RKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQL
LKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGV
VEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCL
PFLQPGRLVKVKNEGDDFGWGVVVNFSKKSLYVVEVLLRCAAKPAKPDEK
GEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDG
IPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCE
KKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMK
GRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPK
LTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTW
ATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKF
AEGITKIKRDIVFAASLYL

Ligand information

>6ro1 Chain B (length=18) Species: 9606 (Homo sapiens)

GWFIDKTPSVKKDSFFLD

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ro1 The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
• Resolution: 3.07 Å
• Binding residue (original residue number in PDB): P652 F653 Q655 R658 S741 V742 R743 Y745 V766
• Binding residue (residue number reindexed from 1): P551 F552 Q554 R557 S618 V619 R620 Y622 V643

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003724 RNA helicase activity
• GO:0004386 helicase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0000398 mRNA splicing, via spliceosome
• GO:0000460 maturation of 5.8S rRNA
• GO:0006364 rRNA processing
• GO:0006397 mRNA processing
• GO:0006401 RNA catabolic process
• GO:0006974 DNA damage response
• GO:0008380 RNA splicing
• GO:0016076 snRNA catabolic process

Cellular Component

• GO:0000176 nuclear exosome (RNase complex)
• GO:0000178 exosome (RNase complex)
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005681 spliceosomal complex
• GO:0005730 nucleolus
• GO:0016607 nuclear speck
• GO:0031499 TRAMP complex
• GO:0071013 catalytic step 2 spliceosome

External links

• PDB: RCSB:6ro1, PDBe:6ro1, PDBj:6ro1
• PDBsum: 6ro1
• PubMed: 31358741
• UniProt: P42285|MTREX_HUMAN Exosome RNA helicase MTR4 (Gene Name=MTREX)