Structure of PDB 6rnr Chain A Binding Site BS01

Receptor Information
>6rnr Chain A (length=266) Species: 1359 (Lactococcus cremoris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PELPEVETVRRELEKRIVGQKIISIEATYPRMVLTGFEQLKKELTGKTIQ
GISRRGKYLIFEIGDDFRLISHLRMEGKYRLATLDAPREKHDHLTMKFAD
GQLIYADVRKFGTWELISTDQVLPYFLKKKIGPEPTYEDFDEKLFREKLR
KSTKKIKPYLLEQTLVAGLGNIYVDEVLWLAKIHPEKETNQLIESSIHLL
HDSIIEILQKAIKLGGSSALGSTGKMQNELQVYGKTGEKCSRCGAEIQKI
KVAGRGTHFCPVCQQK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rnr Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights.
Resolution2.003 Å
Binding residue
(original residue number in PDB)		E2 K57 H72 R74 M75 R109 G170 N171 I172 Y238 K254 K256 R260
Binding residue
(residue number reindexed from 1)		E2 K57 H72 R74 M75 R109 G170 N171 I172 Y233 K249 K251 R255
Enzymatic activity
Enzyme Commision number 3.2.2.23: DNA-formamidopyrimidine glycosylase.
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6rnr, PDBe:6rnr, PDBj:6rnr
PDBsum6rnr
PubMed32192183
UniProtP42371|FPG_LACLC Formamidopyrimidine-DNA glycosylase (Gene Name=mutM)

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