Structure of PDB 6r5g Chain A Binding Site BS01
Receptor Information
>6r5g Chain A (length=119) Species:
9606
(Homo sapiens) [
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GPMADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSV
RTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNP
MVETLGTVLQLKQPLNTTR
Ligand information
>6r5g Chain B (length=11) Species:
9606
(Homo sapiens) [
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EQTEYATIVFP
Receptor-Ligand Complex Structure
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PDB
6r5g
Molecular mechanism of SHP2 activation by PD-1 stimulation.
Resolution
N/A
Binding residue
(original residue number in PDB)
R138 S140 Q141 S142 V148 K166 T168 H169 V170 M171 V181 G182 G183 M202 V203 E204 T205 T208
Binding residue
(residue number reindexed from 1)
R37 S39 Q40 S41 V47 K65 T67 H68 V69 M70 V80 G81 G82 M101 V102 E103 T104 T107
Enzymatic activity
Enzyme Commision number
3.1.3.48
: protein-tyrosine-phosphatase.
External links
PDB
RCSB:6r5g
,
PDBe:6r5g
,
PDBj:6r5g
PDBsum
6r5g
PubMed
32064351
UniProt
Q06124
|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)
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