Structure of PDB 6r4x Chain A Binding Site BS01

Receptor Information

>6r4x Chain A (length=195) Species: 1496 (Clostridioides difficile) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MDSTTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKYLNALKQN
NLKIKLLSGKLTDEKEYAYLKGVVPKGWEGTGKTWDDVPGLGGSTVALRI
GFSNKGKGHDAINLELHATAHAIDHIVLNDISKSAQFKQIFAKEGRSLGN
VNFLGVYPEEFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK

Ligand information

>6r4x Chain D (length=7) Species: 1496 (Clostridioides difficile) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

EVNPAVP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6r4x Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
Resolution	1.831 Å
Binding residue (original residue number in PDB)	P100 K101 W103 W110 L116 G117 G118 S119 H134 D135 A136 H142 H146 H150 F178
Binding residue (residue number reindexed from 1)	P75 K76 W78 W85 L91 G92 G93 S94 H109 D110 A111 H117 H121 H125 F153

Enzymatic activity

Enzyme Commision number

3.4.24.89: Pro-Pro endopeptidase.

Gene Ontology

	Molecular Function
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0005576	extracellular region

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External links

PDB	RCSB:6r4x, PDBe:6r4x, PDBj:6r4x
PDBsum	6r4x
PubMed	31182482
UniProt	Q183R7\|PPEP1_CLOD6 Pro-Pro endopeptidase (Gene Name=zmp1)

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