Structure of PDB 6qx8 Chain A Binding Site BS01

Receptor Information

>6qx8 Chain A (length=514) Species: 384505 (Influenza A virus (A/nt/60/1968(H3N2)))

ERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGYIEGKLSQMSKE
VNAKIEPFLKTTPRPIRLPDGPPCFQRSKFLLMDALKLSIEDPSHEGEGI
PLYDAIKCMRTFFGWKEPYIVKPHEKGINPNYLLSWKQVLAELQDIENEE
KIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDVSDLKQYDSDEPELRS
LSSWIQNEFNKACELTDSTWIELDEIGEDVAPIEYIASMRRNYFTAEVSH
CRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYG
FIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRS
AIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSV
KEKDMTKEFFENKSETWPIGESPKGVEDGSIGKVCRTLLAKSVFNSLYAS
PQLEGFSAESRKLLLVVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLL
NASWFNSFLTHALR

Ligand information

>6qx8 Chain D (length=12)

agcaaaagcagg

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 6qx8 Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
• Resolution: 4.07 Å
• Binding residue (original residue number in PDB): K328 W368 A369 L370 G371 E372 M374 A375 P376 E377 K378 Y393 S395 D396 E397 P398 R508 D516 V517 K539 N568 G569 N696
• Binding residue (residue number reindexed from 1): K126 W166 A167 L168 G169 E170 M172 A173 P174 E175 K176 Y191 S193 D194 E195 P196 R306 D314 V315 K337 N366 G367 N494

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6qx8, PDBe:6qx8, PDBj:6qx8
• PDBsum: 6qx8
• PubMed: 31485076
• UniProt: P03434|PA_I68A6 Polymerase acidic protein (Gene Name=PA)