Structure of PDB 6qtk Chain A Binding Site BS01

Receptor Information
>6qtk Chain A (length=484) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RINERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQG
MTPDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQ
GNFGSMDGDGAAAMRFTEARMTKITLELLRDINKDTIDFIDNYDGNEREP
SVLPARFPNLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIA
ELMEDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQ
RIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVID
VRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLE
HQKTVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVA
MESLQQRFKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELET
ILADEEVLLQLVRDELTEIRDRFGDDRRTEIQLG
Ligand information
Receptor-Ligand Complex Structure
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PDB6qtk Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
Resolution2.31 Å
Binding residue
(original residue number in PDB)		R33 K43 H46 H79 H81 S85 R92 I175 R272
Binding residue
(residue number reindexed from 1)		R26 K36 H39 H72 H74 S78 R85 I168 R265
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6qtk, PDBe:6qtk, PDBj:6qtk
PDBsum6qtk
PubMed30757898
UniProtQ99XG5|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)

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