Structure of PDB 6qrn Chain A Binding Site BS01

Receptor Information
>6qrn Chain A (length=140) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIVF
HFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQV
MVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR
Ligand information
Ligand IDRIP
InChIInChI=1S/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3-,4-,5-/m1/s1
InChIKeySRBFZHDQGSBBOR-TXICZTDVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1C(C(C(C(O1)O)O)O)O
OpenEye OEToolkits 1.5.0C1[C@H]([C@H]([C@H]([C@@H](O1)O)O)O)O
CACTVS 3.341O[CH]1CO[CH](O)[CH](O)[CH]1O
CACTVS 3.341O[C@@H]1CO[C@@H](O)[C@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)COC(O)C1O
FormulaC5 H10 O5
Namebeta-D-ribopyranose;
beta-D-ribose;
D-ribose;
ribose;
RIBOSE(PYRANOSE FORM)
ChEMBLCHEMBL1159662
DrugBankDB04286
ZINCZINC000004097544
PDB chain6qrn Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6qrn Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		H53 N65 W72 Q75
Binding residue
(residue number reindexed from 1)		H51 N63 W70 Q73
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004622 lysophospholipase activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042802 identical protein binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
GO:0002667 regulation of T cell anergy
GO:0002724 regulation of T cell cytokine production
GO:0046006 regulation of activated T cell proliferation
GO:0070231 T cell apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0062023 collagen-containing extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qrn, PDBe:6qrn, PDBj:6qrn
PDBsum6qrn
PubMed31123109
UniProtQ05315|LEG10_HUMAN Galectin-10 (Gene Name=CLC)

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