Structure of PDB 6qbt Chain A Binding Site BS01

Receptor Information
>6qbt Chain A (length=148) Species: 11909 (Human T-lymphotropic virus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RGLLPNHIWQGDVTHYKYKKYKYCLHVWVDTFSGAVSVSCKKKETSCETI
SAFLQAISLLGKPLHINTDNGPAFLSQEFQEFCTSYHIKHSTHGLVERTN
GIIKNLLNKYLLDCPNLPLDNAINKALWTLNQLNVMNPSGKTRWQIHH
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6qbt Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6qbt Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56 gamma.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		D65 D122
Binding residue
(residue number reindexed from 1)		D12 D69
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:6qbt, PDBe:6qbt, PDBj:6qbt
PDBsum6qbt
PubMed33028863
UniProtP03363|POL_HTLV2 Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)

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