Structure of PDB 6pzd Chain A Binding Site BS01

Receptor Information

>6pzd Chain A (length=389) Species: 1332244 (Influenza A virus (A/Shanghai/02/2013(H7N9)))

RRNFNNLTKGLCTINSWHIYGKDNAVRIGESSDVLVTREPYVSCDPDECR
FYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVHNSRVECIGWS
STSCHDGKSRMSICISGPNNNASAVVWYNRRPVAEINTWARNILRTQESE
CVCHNGVCPVVFTDGSATGPADTRIYYFKEGKILKWESLTGTAKHIEECS
CYGERTGITCTCRDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPN
DPNIGKCNDPYPGNNNNGVKGFSYLDGANTWLGRTISTASRSGYEMLKVP
NALTDDRSKPIQGQTIVLNADWSGYSGSFMDYWAEGDCYRACFYVELIRG
RPKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6pzd Chain A Residue 518

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6pzd Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.
• Resolution: 1.12 Å
• Binding residue (original residue number in PDB): D293 G297 D324 N347
• Binding residue (residue number reindexed from 1): D214 G218 D245 N267
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0046761 viral budding from plasma membrane

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:6pzd, PDBe:6pzd, PDBj:6pzd
• PDBsum: 6pzd
• PubMed: 31757767
• UniProt: R4NFR6