Structure of PDB 6pz3 Chain A Binding Site BS01

Receptor Information
>6pz3 Chain A (length=429) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAA
IERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIR
KIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCR
GIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLT
KDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVI
KNMNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB6pz3 Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.
Resolution2.395 Å
Binding residue
(original residue number in PDB)		S113 E116 K224 S257 G259 G260 K261 L262 L381 R382 C384
Binding residue
(residue number reindexed from 1)		S113 E116 K221 S254 G256 G257 K258 L259 L378 R379 C381
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6pz3, PDBe:6pz3, PDBj:6pz3
PDBsum6pz3
PubMed31704958
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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