Structure of PDB 6pww Chain A Binding Site BS01

Receptor Information
>6pww Chain A (length=333) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIH
PVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHP
RDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIY
TGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINT
ADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIV
AGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGV
VSIWAQNQVENWSAFKELDENVEYEERESEFDI
Ligand information
>6pww Chain P (length=146) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcggatgtatatatctgacacgtgcctggagactagggagtaatcccct
tggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgcta
gagctgtctacgaccaattgagcggcctcggcaccgggattctcga
Receptor-Ligand Complex Structure
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PDB6pww Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		R220 R272 R294
Binding residue
(residue number reindexed from 1)		R203 R255 R277
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0005515 protein binding
GO:0042393 histone binding
Biological Process
GO:0006325 chromatin organization
GO:0006974 DNA damage response
GO:0043627 response to estrogen
GO:0045815 transcription initiation-coupled chromatin remodeling
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0035097 histone methyltransferase complex
GO:0044665 MLL1/2 complex
GO:0044666 MLL3/4 complex
GO:0048188 Set1C/COMPASS complex
GO:0071339 MLL1 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pww, PDBe:6pww, PDBj:6pww
PDBsum6pww
PubMed31804488
UniProtQ15291|RBBP5_HUMAN Retinoblastoma-binding protein 5 (Gene Name=RBBP5)

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