Structure of PDB 6pwu Chain A Binding Site BS01

Receptor Information
>6pwu Chain A (length=615) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENLWVTVYYGVPVWKDAETTLFCASDAKAYDTEVHNVWATHACVPTDPNP
QEIYMENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVQLTPLCVTLDC
SYNITNNITNSITNSSVNMREEIKNCSFNMTTELRDKNRKVYSLFYKLDV
VQINNGNNSSNLYRLINCNTSALTQACPKVTFEPIPIRYCAPAGYAILKC
NDKEFNGTGLCKNVSTVQCTHGIRPVVSTQLLLNGSLAEGKVMIRSENIT
NNVKNIIVQLNETVTINCTRPNNNTRKSVRIGPGQTFYATGDIIGDIRQA
HCNVSGSQWNRALHQVVGQLREYWNTTIIFKNSSGGDLEITTHSFNCGGE
FFYCNTSGLFNSNWTHNDTASMKPNDTITLPCRIKQIINMWQRVGQAIYA
PPIQGVIRCESNITGLILTRDGGGNINESQIFRPGGGDMRDNWRSELYKY
KVVRIEPLGVAPTKAKRRVVEGFLGTAGSTMGAASITLTVQVRKLLSGIV
QQQSNLLRAIEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCS
GKLICTTNVPWNSSWSNKSEREIWENMTWLQWDKEISNYTHIIYELIEES
QKQQEKNEQELLELD
Ligand information
Ligand IDFUC
InChIInChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1
InChIKeySHZGCJCMOBCMKK-SXUWKVJYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)C
OpenEye OEToolkits 1.5.0CC1C(C(C(C(O1)O)O)O)O
OpenEye OEToolkits 1.5.0C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O
CACTVS 3.341C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
FormulaC6 H12 O5
Namealpha-L-fucopyranose;
alpha-L-fucose;
6-deoxy-alpha-L-galactopyranose;
L-fucose;
fucose
ChEMBLCHEMBL1232862
DrugBankDB04473
ZINCZINC000001532814
PDB chain6pwu Chain j Residue 4 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6pwu Cryo-EM Structure of Full-length HIV-1 Env Bound With the Fab of Antibody PG16.
Resolution6.2 Å
Binding residue
(original residue number in PDB)		T136 Y173 D323
Binding residue
(residue number reindexed from 1)		T105 Y142 D292
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity
Biological Process
GO:0006915 apoptotic process
GO:0019049 virus-mediated perturbation of host defense response
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0075512 clathrin-dependent endocytosis of virus by host cell
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044174 host cell endosome
GO:0044175 host cell endosome membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pwu, PDBe:6pwu, PDBj:6pwu
PDBsum6pwu
PubMed31931014
UniProtQ71014

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