Structure of PDB 6pw2 Chain A Binding Site BS01

Receptor Information
>6pw2 Chain A (length=147) Species: 10377 (Human herpesvirus 4 strain B95-8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGGWFGKHRGQGGSNPKFENIAEGLRALLARSHVERTTDEGTWVAGVFVY
GGSKTSLYNLRRGTALAIPQCRLTPLSRLPFGMAPGPGPQPGPLRESIVC
YFMVFLQTHIFAEVLKDAIKDLVMTKPAPTCNIRVTVCSFDDGVDLP
Ligand information
>6pw2 Chain E (length=57) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
accctaattcgatagcatatgcttcccgttgggtaacatatgctattgaa
ttagggt
Receptor-Ligand Complex Structure
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PDB6pw2 Structural Basis for Cooperative Binding of EBNA1 to the Epstein-Barr Virus Dyad Symmetry Minimal Origin of Replication.
Resolution3.01 Å
Binding residue
(original residue number in PDB)		K461 W464 F465 R469 G470 G472 G473 K514 Y518 R522 P535 L536 R538 P587
Binding residue
(residue number reindexed from 1)		K1 W4 F5 R9 G10 G12 G13 K54 Y58 R62 P75 L76 R78 P127
Binding affinityPDBbind-CN: Kd=35.5nM
Enzymatic activity
Enzyme Commision number 3.1.21.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006275 regulation of DNA replication
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pw2, PDBe:6pw2, PDBj:6pw2
PDBsum6pw2
PubMed31142669
UniProtP03211|EBNA1_EBVB9 Epstein-Barr nuclear antigen 1 (Gene Name=EBNA1)

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