Structure of PDB 6puw Chain A Binding Site BS01

Receptor Information

>6puw Chain A (length=249) Species: 11698,273057

FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAM
HGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYF
LLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGV
IESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERI
VDIIATDIQTKELQKQITKIQNFRVGPAKLLWKGEGAVVIQIKVVAKII

Ligand information

>6puw Chain E (length=19)

actgctagagattttcccg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6puw Structural basis for strand-transfer inhibitor binding to HIV intasomes.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): H51 G52 Q53 V54 G140 I141 N144 Q146 S147 G149 V150 S153 M154 E157
• Binding residue (residue number reindexed from 1): H51 G52 Q53 V54 G140 I141 N144 Q146 S147 G149 V150 S153 M154 E157

Enzymatic activity

• Enzyme Commision number:
  2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0004521 RNA endonuclease activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0015074 DNA integration

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6puw, PDBe:6puw, PDBj:6puw
• PDBsum: 6puw
• PubMed: 32001521
• UniProt: P12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol);
  P39476|DN7D_SACS2 DNA-binding protein 7d (Gene Name=sso7d)