Structure of PDB 6pmp Chain A Binding Site BS01

Receptor Information
>6pmp Chain A (length=609) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPNISMCHQGLLSFEGFA
RFLMDKDNFASKNDESRENKKDLQLPLSYYYIESSHNTYLTGHQLKGESS
VELYSQVLLQGCRSIELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDR
SAFITSDLPIIISIENHCSLPQQRKMAEIFKSVFGEKLVAKFLFETDFSD
DPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASMQESRQIAPE
LSDLVIYCQAVKFPGLRTPKCYHISSLNENAAKRLCRRYSQKLIQHTACQ
LLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEAN
GGCGYVLKPPVLWDKSCPMYQKFSPLERDLDAMDPATYSLTIISGQNVCP
SNSTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFRVHFEDL
VFLRFAVVENNSSAITAQRIIPLKALKRGYRHLQLRNLHNEILEISSLFI
NSRRMEDTRPASLMFNTEERKCSQTHKVTVHGVPGPEPFAVFTINEGTKA
KQLLQQILAVDQDYFLMEEKHFIKQPFQRAVGPEEDIVQILNSWFPEEGY
VGRIVLKPQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6pmp Chain A Residue 2100 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6pmp Structure of phospholipase C epsilon reveals an integrated RA1 domain and previously unidentified regulatory elements.
Resolution2.73 Å
Binding residue
(original residue number in PDB)		N1389 D1420 E1467
Binding residue
(residue number reindexed from 1)		N87 D118 E165
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H1388 N1389 E1418 D1420 H1433 E1467
Catalytic site (residue number reindexed from 1) H86 N87 E116 D118 H131 E165
Enzyme Commision number 3.1.4.11: phosphoinositide phospholipase C.
Gene Ontology
Molecular Function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6pmp, PDBe:6pmp, PDBj:6pmp
PDBsum6pmp
PubMed32796910
UniProtQ99P84|PLCE1_RAT 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (Gene Name=Plce1)

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