Structure of PDB 6pgw Chain A Binding Site BS01

Receptor Information
>6pgw Chain A (length=427) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VFDEPVYTVNVLENSPINTLVIDLNATDPDEGTNGEVVYSFINFVSNLTK
QMFKIDPKTGVITVNGVLDHEELHIHEIDVQAKDLGPNSIPAHCKVIVNV
IDINDNAPEIKLLSENSEMVEVSENAPLGYVIALVRVSDNDSGANGKVQC
RLQGNVPFRLNEFESFSTLLVDGRLDREQRDMYNLTILAEDSGYPPLRSS
KSFAVKVTDENDNPPYFTKPHYQAMVLENNVPGAFLLAVSARDPDLGMNG
TVSYEIIKSEVRGMSVESYVTVNSNGEIYGVRAFNHEDTRTFEFKVSAKD
GGDPPLTSNATVRIVVLDVNDNTPVMTTPPLVNGTAEVSIPKNAGVGYLV
TQIKADDYDEGENGRLTYSISEGDMAYFEIDQINGEVRTTKTFGENAKPS
YQITVVAHDHGQTSLSASAYIVIYLSP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6pgw Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6pgw A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E226 D282 E284 D318
Binding residue
(residue number reindexed from 1)		E13 D69 E71 D105
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pgw, PDBe:6pgw, PDBj:6pgw
PDBsum6pgw
PubMed34520737
UniProtF8W3X3|PCD19_DANRE Protocadherin-19 (Gene Name=pcdh19)

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