Structure of PDB 6pfo Chain A Binding Site BS01

Receptor Information
>6pfo Chain A (length=474) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFP
QVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVR
YNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALM
FNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDL
IKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLP
TFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKP
LGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVI
NAASGRQTVDEALKDAQTNAAAEFPFLYVVGRKKMMDAQYKCYDRMQQLP
AYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCD
EKGVWFKHPENNRTWSNYTMCNAF
Ligand information
>6pfo Chain C (length=17) Species: 8025 (Oncorhynchus sp.) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
LHKLQTYPRTNTGSGTP
Receptor-Ligand Complex Structure
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PDB6pfo Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics.
Resolution1.78 Å
Binding residue
(original residue number in PDB)		Q-263 Y-236 N-235 D-158 I-157 P-1 Q0 F37 L40 Y41 D77 W79 F99 P100 D101 H121 E123 W128 S129 N135 F137
Binding residue
(residue number reindexed from 1)		Q74 Y101 N102 D179 I180 P336 Q337 F374 L377 Y378 D414 W416 F436 P437 D438 H458 E460 W465 S466 N472 F474
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0015144 carbohydrate transmembrane transporter activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pfo, PDBe:6pfo, PDBj:6pfo
PDBsum6pfo
PubMed32035902
UniProtP30988|CALCR_HUMAN Calcitonin receptor (Gene Name=CALCR)

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