Structure of PDB 6pek Chain A Binding Site BS01

Receptor Information

>6pek Chain A (length=283) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLR
APARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL
VRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGV
DRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGS
PLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEM
RNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKD

Ligand information

>6pek Chain G (length=10) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

EYEYEYEYEY

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6pek Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
Resolution	4.2 Å
Binding residue (original residue number in PDB)	Y415 H455
Binding residue (residue number reindexed from 1)	Y93 H133

Enzymatic activity

Enzyme Commision number

5.6.1.1: microtubule-severing ATPase.

Gene Ontology

	Molecular Function
GO:0005524	ATP binding
GO:0008568	microtubule severing ATPase activity
GO:0016887	ATP hydrolysis activity

View graph for
Molecular Function

External links

PDB	RCSB:6pek, PDBe:6pek, PDBj:6pek
PDBsum	6pek
PubMed	31767681
UniProt	Q9UBP0\|SPAST_HUMAN Spastin (Gene Name=SPAST)

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