Structure of PDB 6pdz Chain A Binding Site BS01

Receptor Information

>6pdz Chain A (length=256) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKHIAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVT
LLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP
KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQA
LELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTLHPLLQE
IYKDLY

Ligand information

>6pdz Chain D (length=12) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

MGLEAIIRKALM

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6pdz A molecular switch regulating transcriptional repression and activation of PPAR gamma.
Resolution	2.1 Å
Binding residue (original residue number in PDB)	V293 T297 K301 L311 V315 L318 K319 H323
Binding residue (residue number reindexed from 1)	V77 T81 K85 L95 V99 L102 K103 H107

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:6pdz, PDBe:6pdz, PDBj:6pdz
PDBsum	6pdz
PubMed	32075969
UniProt	P37231\|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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