Structure of PDB 6pbd Chain A Binding Site BS01

Receptor Information

>6pbd Chain A (length=350) Species: 155892 (Caulobacter vibrioides)

MKFGPETIIHGDCIEQMNALPEKSVDLIFADPPYNLQLGGDLLRPDNSKV
DAVDDHWDQFESFAAYDKFTREWLKAARRVLKDDGAIWVIGSYHNIFRVG
VAVQDLGFWILNDIVWRKSNPMPNFKGTRFANAHETLIWASKSQNAKRYT
FNYDALKMANDEVQMRSDWTIPLCTGEERIKGADGQKAHPTQKPEALLYR
VILSTTKPGDVILDPFFGVGTTGAAAKRLGRKFIGIEREAEYLEHAKARI
AKVVPIAPEDRAEPRVPFGTIVEAGLLSPGDTLYCSKGTHVAKVRPDGSI
TVGDLSGSIHKIGALVQSAPACNGWTYWHFKTDAGLAPIDVLRAQVRAGM

Ligand information

>6pbd Chain X (length=19)

cgattcaatgaatcccaag

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6pbd The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site.
• Resolution: 2.343 Å
• Binding residue (original residue number in PDB): D31 Y34 L36 Q37 L38 G40 L42 R44 A52 D58 Y93 H94 P121 M122 N124 F125 K126 T128 R129 N132 L173 R179 K187 P190 T191 K193
• Binding residue (residue number reindexed from 1): D31 Y34 L36 Q37 L38 G40 L42 R44 A52 D58 Y93 H94 P121 M122 N124 F125 K126 T128 R129 N132 L173 R179 K187 P190 T191 K193

Enzymatic activity

• Enzyme Commision number: 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0008168 methyltransferase activity
• GO:0008170 N-methyltransferase activity
• GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity

Biological Process

• GO:0006260 DNA replication
• GO:0032259 methylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6pbd, PDBe:6pbd, PDBj:6pbd
• PDBsum: 6pbd
• PubMed: 31601797
• UniProt: P0CAW2|CCRM_CAUVC DNA methyltransferase CcrM (Gene Name=ccrMIM)