Structure of PDB 6pbc Chain A Binding Site BS01

Receptor Information
>6pbc Chain A (length=1070) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSIEGSIDI
REIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQAT
SEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRISAKDLKNM
LSQVNYRVPDITYGQFAQLYRSLMYSAQKTMDLPFCQVSLSEFQQFLLEY
QGELWAVDRLQVQEFMLSFLRDIEEPYFFLDELVTFLFSKENSVWNSQLD
AVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIE
LDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIED
HCSIAQQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKK
LAEGSNDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETLHSSE
KWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLS
FWRNGKVQHCRIHSRQPKFFLTDNLVFDSLYDLITHYQQVPLRFEMRLSE
PVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAIS
FRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYP
INEEALEKIGTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWR
GDYGGKKQLWFPSNYVEEMINPAILEPEREHLDENSPLGDLLRGVLDVPA
CQIAIRPEGKNNRLFVFSISMPSVAQWSLDVAADSQEELQDWVKKIREVA
QTKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKA
KGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDK
PMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCVICIEVL
GARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPF
HFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNN
YSEDLELASLLIKIDIFPAK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6pbc Chain A Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6pbc Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations.
Resolution2.46 Å
Binding residue
(original residue number in PDB)		N336 E365 D367 E414
Binding residue
(residue number reindexed from 1)		N271 E300 D302 E349
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H335 N336 E365 D367 H380 E414
Catalytic site (residue number reindexed from 1) H270 N271 E300 D302 H315 E349
Enzyme Commision number 3.1.4.11: phosphoinositide phospholipase C.
Gene Ontology
Molecular Function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005509 calcium ion binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0009395 phospholipid catabolic process
GO:0035556 intracellular signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6pbc, PDBe:6pbc, PDBj:6pbc
PDBsum6pbc
PubMed31889510
UniProtG3V845

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