Structure of PDB 6p4w Chain A Binding Site BS01

Receptor Information

>6p4w Chain A (length=435) Species: 273063 (Sulfurisphaera tokodaii str. 7)

GSVYLRYFKGLILSDAYAPGLKWSDELKAYSALAFKYRDVRKYFLEKEIE
VEENVIDSLPFPLIKDKIELRDYQAEAVKAWLKEKRGIIVLPTGAGKTQV
ALKIVSIMKVATLIVVPTIDLITQWKERINKYLDFDPGIIGGGEDSLKGI
TVITYDSAYTRAEELGNKFPLLIFDEVHHLPSEGYSIMAQLFASPYRLGL
TATPERDDGKHELYPILVGPIVYRKSVEELAGKYIAKYKIKKLYVSLTNE
EKKRYDGLRKKLKDFLSSRGLKLQNLDDFHRLVKLAAKDKEAREALLAWH
ESLNIAVNSQSKIEKLREILQEYKNEKIIVFTRDTQMAYRISKTFLIPVV
TYKTDKDEREEILQKFRDGEYRVIVASTVFDEGVDVPDATLAIVMGGYGT
KRQFLQRLGRILRKKDKEALLIEIVTKGTADYRLS

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6p4w Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6p4w XPB helicase in a complex with truncated Bax1 from Sulfurisphaera tokodaii at 2.96 Angstrom resolution
• Resolution: 2.956 Å
• Binding residue (original residue number in PDB): K96 D174
• Binding residue (residue number reindexed from 1): K97 D175
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.6.2.4: DNA 3'-5' helicase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016853 isomerase activity
• GO:0140097 catalytic activity, acting on DNA

Biological Process

• GO:0006281 DNA repair
• GO:0071103 DNA conformation change

External links

• PDB: RCSB:6p4w, PDBe:6p4w, PDBj:6p4w
• PDBsum: 6p4w
• UniProt: Q970I2|XPB2_SULTO DNA 3'-5' translocase XPB2 (Gene Name=xpb2)