Structure of PDB 6p23 Chain A Binding Site BS01

Receptor Information
>6p23 Chain A (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHSMRYFDTAMSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAP
WIEQEGPEYWDRNTQIFKTNTQTDRCSLRNLRGYYNQSEAGSHTLQSMYG
CDVGPDGRLLRGHNQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAA
RVAEQDRAYLEGTCVEWLRRYLENGKDTLERADPPKTHVTHHPISDHEAT
LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVP
SGEEQRYTCHVQHEGLPKPLTLRWE
Ligand information
>6p23 Chain C (length=9) Species: 11676 (Human immunodeficiency virus 1) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAKKKYCL
Receptor-Ligand Complex Structure
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PDB6p23 ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation.
Resolution1.595 Å
Binding residue
(original residue number in PDB)		D9 N63 I66 F67 N70 T73 D74 C76 S77 N80 Y84 S97 Y123 T143 K146 W147 V152 Q155 D156 Y159 W167
Binding residue
(residue number reindexed from 1)		D9 N63 I66 F67 N70 T73 D74 C76 S77 N80 Y84 S97 Y123 T143 K146 W147 V152 Q155 D156 Y159 W167
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6p23, PDBe:6p23, PDBj:6p23
PDBsum6p23
PubMed31601650
UniProtP01889|HLAB_HUMAN HLA class I histocompatibility antigen, B alpha chain (Gene Name=HLA-B)

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