Structure of PDB 6p0c Chain A Binding Site BS01

Receptor Information
>6p0c Chain A (length=642) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMV
ETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVA
QATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFR
DIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSV
LAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCE
VPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFE
EAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIK
LPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYA
FDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAE
FLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDL
VVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHH
QSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAAR
GLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQS
Ligand information
Receptor-Ligand Complex Structure
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PDB6p0c Two-tiered enforcement of high-fidelity DNA ligation.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		E346 L347 G348 V349 G350 G352 V353 G571 Q572 S588 E592 F635 F872
Binding residue
(residue number reindexed from 1)		E87 L88 G89 V90 G91 G93 V94 G312 Q313 S329 E333 F376 F613
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6p0c, PDBe:6p0c, PDBj:6p0c
PDBsum6p0c
PubMed31780661
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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