Structure of PDB 6ou1 Chain A Binding Site BS01

Receptor Information
>6ou1 Chain A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GCGELVWVGEPVTLRTAETITGKYGVWMRDPKPVYPYTQETTWRIDTVGT
DVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYNGSLYFQGAGSRT
VIRYDLKTETVKAEKEIPGAGYHGQYPYSWGGYTDIDLAVDENGLWVIYS
TNQAKGNIVLSKLNPETLEVEQTWETNIRKQSVANAFIICGTLYTVSSYT
SADATVNFAYDTNTGTSKYLDIPFKNRYKYNSMIDYNPLERKLFAWDNGH
MVTYDIKLSK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6ou1 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ou1 Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations.
Resolution1.878 Å
Binding residue
(original residue number in PDB)		D380 N428 A429 I477 D478
Binding residue
(residue number reindexed from 1)		D137 N185 A186 I234 D235
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6ou1, PDBe:6ou1, PDBj:6ou1
PDBsum6ou1
PubMed31270212
UniProtQ99972|MYOC_HUMAN Myocilin (Gene Name=MYOC)

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