Structure of PDB 6os2 Chain A Binding Site BS01

Receptor Information

>6os2 Chain A (length=380) Species: 562,9606

IKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSF
NLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLAS
LPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLI
ILTSYTLIWKALKKAYDLEDNWETLNDNLKVIEKADNAAQVKDALTKMRA
AALDAQKAHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKKNKPRNDDI
FKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITI
CIAYFNNCLNPLFYGFLGKKFKRYFLQLLK

Ligand information

>6os2 Chain B (length=7) Species: 32630 (synthetic construct)

GRVYYHP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6os2 Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): Q15 D16 D17 A21 G22 R23 W84 Y87 Y92 R167 A181 F182 H183 Y184 D1263 I1266 D1281 M1284
• Binding residue (residue number reindexed from 1): Q5 D6 D7 A11 G12 R13 W74 Y77 Y82 R157 A171 F172 H173 Y174 D325 I328 D343 M346

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004945 angiotensin type II receptor activity
• GO:0005506 iron ion binding
• GO:0009055 electron transfer activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0019229 regulation of vasoconstriction
• GO:0022900 electron transport chain

Cellular Component

• GO:0016020 membrane
• GO:0042597 periplasmic space

External links

• PDB: RCSB:6os2, PDBe:6os2, PDBj:6os2
• PDBsum: 6os2
• PubMed: 32079768
• UniProt: P0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
  P30556