Structure of PDB 6os1 Chain A Binding Site BS01

Receptor Information

>6os1 Chain A (length=381) Species: 562,9606

IKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSF
NLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLAS
LPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLI
ILTSYTLIWKALKKAYDLEDNWETLNDNLKVIEKADNAAQVKDALTKMRA
AALDAQKARHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKKNKPRNDD
IFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPIT
ICIAYFNNCLNPLFYGFLGKKFKRYFLQLLK

Ligand information

>6os1 Chain B (length=8) Species: 32630 (synthetic construct)

GRVYKHPA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6os1 Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
• Resolution: 2.794 Å
• Binding residue (original residue number in PDB): D17 W84 Y87 V108 R167 A181 Y184 K199 D1263 D1281 M1284 I1288
• Binding residue (residue number reindexed from 1): D7 W74 Y77 V98 R157 A171 Y174 K189 D326 D344 M347 I351

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004945 angiotensin type II receptor activity
• GO:0005506 iron ion binding
• GO:0009055 electron transfer activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0019229 regulation of vasoconstriction
• GO:0022900 electron transport chain

Cellular Component

• GO:0016020 membrane
• GO:0042597 periplasmic space

External links

• PDB: RCSB:6os1, PDBe:6os1, PDBj:6os1
• PDBsum: 6os1
• PubMed: 32079768
• UniProt: P0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
  P30556