Structure of PDB 6os0 Chain A Binding Site BS01

Receptor Information

>6os0 Chain A (length=395) Species: 562,9606

DGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMK
LKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASV
SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGL
ASLPAIIHRNVFFIENTNITVCAFHYESQNLPIGLGLTKNILGFLFPFLI
ILTSYTLIWKALKKAYDLEDNWETLNDNLKVIEKADNAAQVKDALTKMRA
AALDAQKATPPPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQL
KTTRAEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGII
RDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQL

Ligand information

>6os0 Chain B (length=8) Species: 9606 (Homo sapiens)

DRVYIHPF

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6os0 Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): Q15 D17 R23 W84 Y87 Y92 S109 R167 A181 F182 Y184 K199 D1263 D1281 M1284
• Binding residue (residue number reindexed from 1): Q7 D9 R15 W76 Y79 Y84 S101 R159 A173 F174 Y176 K189 D342 D360 M363

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004945 angiotensin type II receptor activity
• GO:0005506 iron ion binding
• GO:0009055 electron transfer activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0019229 regulation of vasoconstriction
• GO:0022900 electron transport chain

Cellular Component

• GO:0016020 membrane
• GO:0042597 periplasmic space

External links

• PDB: RCSB:6os0, PDBe:6os0, PDBj:6os0
• PDBsum: 6os0
• PubMed: 32079768
• UniProt: P0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
  P30556