Structure of PDB 6opj Chain A Binding Site BS01

Receptor Information
>6opj Chain A (length=467) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSVPVLTFQSEKMKGMKELLVATKIN
SSAIKLQLTAQSQVQMK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6opj Covalent and noncovalent constraints yield a figure eight-like conformation of a peptide inhibiting the menin-MLL interaction.
Resolution1.50066 Å
Binding residue
(original residue number in PDB)		D136 D153 S155 E179 D180 H181 A182 F238 C241 M278 N282 Y319 Y323 E359
Binding residue
(residue number reindexed from 1)		D115 D132 S134 E158 D159 H160 A161 F217 C220 M257 N261 Y298 Y302 E338
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

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Cellular Component
External links
PDB RCSB:6opj, PDBe:6opj, PDBj:6opj
PDBsum6opj
PubMed32882610
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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