Structure of PDB 6oog Chain A Binding Site BS01

Receptor Information
>6oog Chain A (length=252) Species: 6204 (Taenia solium) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHMTRKLFVGGNWKMNGSYSHINTFFDTLQKADTDPNADIVIGVPACYLK
YAQDKAPKGIKIAAENCYKVGSGAFTGEISTEMIKDCGCEWVILGHSERR
HIFGESNELIGEKVKHALDSGLNVIPCIGELLSEREAGKTNDVCFAQMDA
IAKNVPSKEAWDKVVIAYEPVWAIGTGKTATPAQAQEVHKVVRDWIRKHV
DAGIADKVRILYGGSVTASNAKDLGTQPDVDGFLVGGASLKPDFITIINA
RR
Ligand information
Ligand IDPGA
InChIInChI=1S/C2H5O6P/c3-2(4)1-8-9(5,6)7/h1H2,(H,3,4)(H2,5,6,7)
InChIKeyASCFNMCAHFUBCO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC(=O)CO[P](O)(O)=O
OpenEye OEToolkits 1.5.0C(C(=O)O)OP(=O)(O)O
ACDLabs 10.04O=P(O)(O)OCC(=O)O
FormulaC2 H5 O6 P
Name2-PHOSPHOGLYCOLIC ACID
ChEMBLCHEMBL47181
DrugBankDB02726
ZINCZINC000003869735
PDB chain6oog Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6oog Crystal structures of Triosephosphate Isomerases from Taenia solium and Schistosoma mansoni provide insights for vaccine rationale and drug design against helminth parasites.
Resolution2.02 Å
Binding residue
(original residue number in PDB)		K12 H94 E167 I172 G173 S213 G234 G235
Binding residue
(residue number reindexed from 1)		K14 H96 E169 I174 G175 S215 G236 G237
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) N10 K12 H94 E96 E167 G173 S213
Catalytic site (residue number reindexed from 1) N12 K14 H96 E98 E169 G175 S215
Enzyme Commision number 5.3.1.1: triose-phosphate isomerase.
Gene Ontology
Molecular Function
GO:0004807 triose-phosphate isomerase activity
GO:0016853 isomerase activity
Biological Process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0019563 glycerol catabolic process
GO:0046166 glyceraldehyde-3-phosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6oog, PDBe:6oog, PDBj:6oog
PDBsum6oog
PubMed31923219
UniProtQ9GTX8|TPIS_TAESO Triosephosphate isomerase

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