Structure of PDB 6onj Chain A Binding Site BS01

Receptor Information
>6onj Chain A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTSPFVIYDMNSLMMGEDKI
KHITPLEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLK
YGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFE
FAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALEL
QLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLL
QEIYKDLY
Ligand information
Receptor-Ligand Complex Structure
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PDB6onj A molecular switch regulating transcriptional repression and activation of PPAR gamma.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		T297 K301 N312 Q314 V315 L318 K319 P467 L468 E471 K474
Binding residue
(residue number reindexed from 1)		T78 K82 N93 Q95 V96 L99 K100 P248 L249 E252 K255
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6onj, PDBe:6onj, PDBj:6onj
PDBsum6onj
PubMed32075969
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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