Structure of PDB 6ohm Chain A Binding Site BS01

Receptor Information
>6ohm Chain A (length=574) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWW
LSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELGINSGYSK
RALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDD
LHYRLTDLGPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPR
MPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSPG
GQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCS
DGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNS
IQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHP
VSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEP
SLMNGAEYQAGRFALSLRKHCFGVILGPDLDLRDPICDDFFQLWQDMAES
NANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGH
LVHFPLKFLEDESLLGMIPLEVWT
Ligand information
Ligand IDWO4
InChIInChI=1S/4O.W/q;;2*-1;
InChIKeyPBYZMCDFOULPGH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-][W](=O)(=O)[O-]
ACDLabs 10.04
CACTVS 3.341		[O-][W]([O-])(=O)=O
FormulaO4 W
NameTUNGSTATE(VI)ION
ChEMBL
DrugBank
ZINC
PDB chain6ohm Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ohm Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Resolution1.895 Å
Binding residue
(original residue number in PDB)		H442 K444 Q642 H756 K758 N773
Binding residue
(residue number reindexed from 1)		H125 K127 Q294 H408 K410 N425
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.4: phospholipase D.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004630 phospholipase D activity
Biological Process
GO:0006654 phosphatidic acid biosynthetic process
GO:0035556 intracellular signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6ohm, PDBe:6ohm, PDBj:6ohm
PDBsum6ohm
PubMed32042197
UniProtO14939|PLD2_HUMAN Phospholipase D2 (Gene Name=PLD2)

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