Structure of PDB 6oh9 Chain A Binding Site BS01

Receptor Information
>6oh9 Chain A (length=452) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKHGKFLVFFGTFVDTPKLGELRIREKTSVGVLNGIIRFVNRNSLDPVKD
CLDHDSSLSPEDVTVVDINNSFYFPGFVDTHNHVSQYPNVGVFGNSTLLD
WLEKYTFPIEAALANENIAREVYNKVISKTLSHGTTTVAYYNTIDLKSTK
LLAQLSSLLGQRVLVGKVCMDTNGPEYYIEDTKTSFESTVKVVKYIRETI
CDPLVNPIVTPRFAPSCSRELMQQLSKLVKDENIHVQTHLSENKEEIQWV
QDLFPECESYTDVYDKYGLLTEKTVLAHCIHLTDAEARVIKQRRCGISHC
PISNSSLTSGECRVRWLLDQGIKVGLGTDVSAGHSCSILTTGRQAFAVSR
HLAMRETDHAKLSVSECLFLATMGGAQVLRMDETLGTFDVGKQFDAQMID
TNAPGSNVDMFHWQLKNPPLLTNEDIIAKWFFNGDDRNTTKVWVAGQQVY
QI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6oh9 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6oh9 Structural Determinants for Substrate Selectivity in Guanine Deaminase Enzymes of the Amidohydrolase Superfamily.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		H100 H102 H258 D348
Binding residue
(residue number reindexed from 1)		H81 H83 H239 D329
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.3: guanine deaminase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008892 guanine deaminase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
Biological Process
GO:0006147 guanine catabolic process
GO:0046098 guanine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6oh9, PDBe:6oh9, PDBj:6oh9
PDBsum6oh9
PubMed31283204
UniProtQ07729|GUAD_YEAST Probable guanine deaminase (Gene Name=GUD1)

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