Structure of PDB 6ogn Chain A Binding Site BS01

Receptor Information
>6ogn Chain A (length=617) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SYADMLHDKDRNIKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAV
TAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIKVINKHSTEVTVGPDGD
LPCRANILITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYAQ
LVESRRMWSWNKLFPVRVRTSLGEQVIVPPSELERCPGAPSVCDIQLNQV
SPADFTVLSDVLPMFSVDFSKQVSSSAACHSRQFVPLASGQAQVVLSWWD
IEMDPEGKIKCTMAPFWAQTDPQELQWRDMQCVYFLPQEEPVVQGSPRCL
VAHHDDYCVWYSLQRTSPQVRPVCDCQAHLLWNRPRFGEINDQDRTDHYA
QALRTVLLPGSVCLCVSDGSLLSMLAHHLGAEQVFTVESSVASYRLMKRI
FKVNHLEDKISVINKRPELLTAADLEGKKVSLLLGEPFFTTSLLPWHNLY
FWYVRTSVDQHLAPGAVVMPQAASLHAVIVEFRDLWRIRSPCGDCEGFDV
HIMDSREAEPHPLWEYPCRSLSKPQEILTFDFQQPIPQQPMQSKGTMELT
RPGKSHGAVLWMEYQLTPDSTISTGLINDCCWNPHCKQAVYFLSRSVSYV
VEFHPLTGDITMEFRLA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6ogn Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ogn Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C219 C366 C368 H371
Binding residue
(residue number reindexed from 1)		C186 C324 C326 H329
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D41 E144 E153
Catalytic site (residue number reindexed from 1) D8 E111 E120
Enzyme Commision number 2.1.1.321: type III protein arginine methyltransferase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0035241 protein-arginine omega-N monomethyltransferase activity
GO:0035243 protein-arginine omega-N symmetric methyltransferase activity
GO:0042393 histone binding
GO:0043021 ribonucleoprotein complex binding
GO:0044020 histone H4R3 methyltransferase activity
GO:0140939 histone H4 methyltransferase activity
Biological Process
GO:0000387 spliceosomal snRNP assembly
GO:0006325 chromatin organization
GO:0006479 protein methylation
GO:0018216 peptidyl-arginine methylation
GO:0030154 cell differentiation
GO:0032259 methylation
GO:0071514 genomic imprinting
Cellular Component
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ogn, PDBe:6ogn, PDBj:6ogn
PDBsum6ogn
PubMed32409666
UniProtQ922X9|ANM7_MOUSE Protein arginine N-methyltransferase 7 (Gene Name=Prmt7)

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