Structure of PDB 6ofs Chain A Binding Site BS01

Receptor Information
>6ofs Chain A (length=905) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AALPQDEKLITGQLDNGLRYMIYPHAHPKDQVNLWLQIHTGSLQEEDNEL
GVAHFVEHMMFNGTKTWPGNKVIETFESMGLRFGRDVNAYTSYDETVYQV
SLPTTQKQNLQQVMAIFSEWSNAATFEKLEVDAERGVITEEWRAHQDAKW
RTSQARRPFLLANTRNLDREPIGLMDTVATVTPAQLRQFYQRWYQPNNMT
FIVVGDIDSKEALALIKDNLSKLPANKAAENRVWPTKAENHLRFNIINDK
ENRVNGIALYYRLPMVQVNDEQSFIEQAEWSMLVQLFNQRLQERIQSGEL
KTISGGTARSVKIAPDYQSLFFRVNARDDNMQDAANALMAELATIDQHGF
SAEELDDVKSTRLTWLKNAVDQQAERDLRMLTSRLASSSLNNTPFLSPEE
TYQLSKRLWQQITVQSLAEKWQQLRKNQDAFWEQMVNNEVAAKKALSPAA
ILALEKEYANKKLAAYVFPGRNLSLTVDADPQAEISSKETLAENLTSLTL
SNGARVILAKSAGEEQKLQIIAVSNKGDLSFPAQQKSLIALANKAVSGSG
VGELSSSSLKRWSAENSVTMSSKVSGMNTLLSVSARTNNPEPGFQLINQR
ITHSTINDNIWASLQNAQIQALKTLDQRPAEKFAQQMYETRYADDRTKLL
QENQIAQFTAADALAADRQLFSSPADITFVIVGNVAEDKLVALITRYLGS
IKHSDSPLAAGKPLTRATDNASVTVKEQNEPVAQVSQWKRYDSRTPVNLP
TRMALDAFNVALAKDLRVNIREQASGAYSVSSRLSVDPQAKDISHLLAFT
CQPERHDELLTLANEVMVKRLAKGISEQELNEYQQNVQRSLDIQQRSVQQ
LANTIVNSLIQYDDPAAWTEQEQLLKQMTVENVNTAVKQYLSHPVNTYTG
VLLPK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6ofs Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ofs Protease-associated import systems are widespread in Gram-negative bacteria.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H80 H84
Binding residue
(residue number reindexed from 1)		H54 H58
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005829 cytosol
GO:0030288 outer membrane-bounded periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ofs, PDBe:6ofs, PDBj:6ofs
PDBsum6ofs
PubMed31613892
UniProtP31828|PQQL_ECOLI Probable zinc protease PqqL (Gene Name=pqqL)

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