Structure of PDB 6oeb Chain A Binding Site BS01

Receptor Information
>6oeb Chain A (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CGRTSCHLPRDVLTRACAYQDRRGQQRLPEWRDPDKYCPSYNKSPQSNSP
VLLSRLHFEKDADSSERIIAPMRWGLVPSWFKESDPSKLQFNTTNCRSDT
VMEKRSFKVPLGKGRRCVVLADGFYEWQRCQGTNQRQPYFIYFPQIKPEN
WEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRM
PAILDGEEAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNT
PECLAPV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6oeb Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		W81 F92 N93 N96 R98 K105 R106 S107 T199 H210 R212
Binding residue
(residue number reindexed from 1)		W80 F91 N92 N95 R97 K104 R105 S106 T186 H197 R199
Binding affinityPDBbind-CN: Kd=720nM
Enzymatic activity
Enzyme Commision number 3.4.-.-
4.-.-.-
Gene Ontology
Molecular Function
GO:0003697 single-stranded DNA binding
Biological Process
GO:0006974 DNA damage response
GO:0106300 protein-DNA covalent cross-linking repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6oeb, PDBe:6oeb, PDBj:6oeb
PDBsum6oeb
PubMed31235913
UniProtQ96FZ2|HMCES_HUMAN Abasic site processing protein HMCES (Gene Name=HMCES)

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