Structure of PDB 6o79 Chain A Binding Site BS01

Receptor Information
>6o79 Chain A (length=706) Species: 342948 (Thermococcus onnurineus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEIDELTALGGLLHDIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEY
ELLSLFSENDELMIRRIKELSPERFGLTMEDVLNALWIVYEADNLASPQA
SRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYRELVKRLWEEL
SKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMTSAIALAMLRA
GCTAEDGRCRKEKRFLLIEGDFSGIQDFIYRVSTLKYLRARSAYLELIGW
DVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPDAVKELEEIRAKAVEWL
YREFESDLYLAIEWEPVSGREFGREGNLFAEARKRLKHKLTVRKLKRFGE
IKGLFECNRLVSLGPKLLGFGRTAKNDAGVLVEGPFSGFVPYLQGGRPVG
EQILVKNTLNPGEIPESAQFVPYFVADYFKKDPKGGVATFEELSMASTGT
RRLGVMKGDVDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGAIIEGKFG
YIIGDVPSLRDWPEEPDIVVVYAGGDAFFIVGAWDQIFELAFRVRRAFNA
YTGGKLTLSVGLGYFDERTPIYRMADVVSERLDTAKDEGRNRVFVVGRSR
PLDGKHKLSYEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGLLWKLLEI
RELYVRDPNDVRWAYLTLSDLFPELVGIDTKAVERKEPQPVYWVDGVLKI
VLMAVR
Ligand information
Receptor-Ligand Complex Structure
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PDB6o79 Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		I243 I247 S263 L266 F290 A292 G293 H295 D521 F529 Y584 G587 D588 A589
Binding residue
(residue number reindexed from 1)		I225 I229 S242 L245 F269 A271 G272 H274 D459 F467 Y522 G525 D526 A527
Enzymatic activity
Enzyme Commision number 2.7.7.-
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6o79, PDBe:6o79, PDBj:6o79
PDBsum6o79
PubMed31326272
UniProtB6YWB8|CAS10_THEON CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=csm1)

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