Structure of PDB 6o78 Chain A Binding Site BS01

Receptor Information
>6o78 Chain A (length=700) Species: 342948 (Thermococcus onnurineus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEIDELTALGGLLHDIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEY
ELLSLFSENDELMIRRIKELSPERFGLTMEDVLNALWIVYEADNLASPQA
SRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYRELVKRLWEEL
SKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMTSAIALAMLRA
GCTAEDGRCRKEKRFLLIEGDFSGIQDFIYRVSTLKYLRARSAYLELIGW
DVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPDAVKELEEIRAKAVEWL
YREFESDLYLAIEWEPVSGREFGREGNLFAEARKRLKHKLTVRKLKRFGE
IKGLFEKLLGFGRTAKNDAGVLVEGPFSGFVPYLQGGRPVGEQILVKNTL
NPGEIPESAQFVPYFVADYFKKDPKGGVATFEELSMASTGTRRLGVMKGD
VDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGAIIEGKFGYIIGDVPSL
RDWPEEPDIVVVYAGGDAFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLS
VGLGYFDERTPIYRMADVVSERLDTAKDEGRNRVFVVGRSRPLDGKHKLS
YEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGLLWKLLEIRELYVRDPN
DVRWAYLTAYLLSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVLMAVR
Ligand information
Receptor-Ligand Complex Structure
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PDB6o78 Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		I243 I247 S263 L266 F290 G293 H295 K360 D521 V522 R524 L525 F529 S542 Y584 G587 D588 K648 R652
Binding residue
(residue number reindexed from 1)		I225 I229 S242 L245 F269 G272 H274 K337 D450 V451 R453 L454 F458 S471 Y513 G516 D517 K577 R581
Enzymatic activity
Enzyme Commision number 2.7.7.-
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6o78, PDBe:6o78, PDBj:6o78
PDBsum6o78
PubMed31326272
UniProtB6YWB8|CAS10_THEON CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=csm1)

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