Structure of PDB 6o75 Chain A Binding Site BS01

Receptor Information
>6o75 Chain A (length=710) Species: 342948 (Thermococcus onnurineus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEIDELTALGGLLHDIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEY
ELLSLFSENDELMIRRIKELSPERFGLTMEDVLNALWIVYEADNLASPQA
SRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYRELVKRLWEEL
SKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMTSAIALAMLRA
GCTAEDVRSGRCRKEKRFLLIEGDFSGIQDFIYRVSTLKYLRARSAYLEL
IGWDVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPDAVKELEEIRAKAV
EWLYREFESDLYLAIEWEPVSGREFGREGGKNLFAEARKRLKHKLTVRKL
KRFGEIKGLFECNRLVSLPKLLGFGRTAKNDAGVLVEGPFSGFVPYLQGG
RPVGEQILVKNTLNPGEIPESAQFVPYFVADYFKKDPKGGVATFEELSMA
STGTRRLGVMKGDVDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGAIIE
GKFGYIIGDVPSLRDWPEEPDIVVVYAGGDAFFIVGAWDQIFELAFRVRR
AFNAYTGGKLTLSVGLGYFDERTPIYRMADVVSERLDTAKDEGRNRVFVV
GRSRPLDGKHKLSYEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGLLWK
LLEIRELYVRDPNDVRWAYLTLSDLFPELVGIDTKAVERKEPQPVYWVDG
VLKIVLMAVR
Ligand information
Receptor-Ligand Complex Structure
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PDB6o75 Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		F290 H295 K360 K367 D523 R524 L525 F529 S542 D546 G587 D588 K648 R652
Binding residue
(residue number reindexed from 1)		F272 H277 K342 K349 D465 R466 L467 F471 S484 D488 G529 D530 K590 R594
Enzymatic activity
Enzyme Commision number 2.7.7.-
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6o75, PDBe:6o75, PDBj:6o75
PDBsum6o75
PubMed31326272
UniProtB6YWB8|CAS10_THEON CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=csm1)

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