Structure of PDB 6o5f Chain A Binding Site BS01

Receptor Information
>6o5f Chain A (length=417) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDWSKPLPPSERLEQELFKYDDIPVEATGNNCPPHIESFSDVEMGEIIMG
NIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIY
SDGPGEALRAMKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYG
GADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRM
LDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIF
LAVENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLED
FLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARSNVKHV
INFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEA
KQEVPSWLENMAYEHHY
Ligand information
>6o5f Chain C (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caaggucauucgcaagaguggcc
.......................
Receptor-Ligand Complex Structure
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PDB6o5f The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X.
Resolution2.504 Å
Binding residue
(original residue number in PDB)		S181 T201 R202 E449 T450 K451 H472 G473 R480 T498 V500 H578 H579
Binding residue
(residue number reindexed from 1)		S38 T58 R59 E290 T291 K292 H313 G314 R321 T339 V341 H415 H416
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6o5f, PDBe:6o5f, PDBj:6o5f
PDBsum6o5f
PubMed31300642
UniProtO00571|DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (Gene Name=DDX3X)

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