Structure of PDB 6o5c Chain A Binding Site BS01

Receptor Information
>6o5c Chain A (length=215) Species: 301448 (Streptococcus pyogenes serotype M3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTPNKEDYLKCIYEIGEQEPKITNKMVAEKMHVSAPAVSEMIKKMISQGW
IVKDKAKGYLLKDKGYALVANLYRKHRLIEVFLIHQLGYNTQEVHQEAEV
LEHTVSDTFIDRLDKILDFPDFCPHGGTIPRYGQPLVEMNTTTLNTITEL
GRFRLSRIHDHFDLIQYLETHHLNINTELTLTQIDTFAKTYTICYGDKEL
VIPENIAKQLYVTAL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6o5c Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6o5c Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R77 E80 C123 H125 D160
Binding residue
(residue number reindexed from 1)		R77 E80 C123 H125 D160
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6o5c, PDBe:6o5c, PDBj:6o5c
PDBsum6o5c
PubMed31188450
UniProtA0A0H2UTK0

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