Structure of PDB 6o16 Chain A Binding Site BS01 |
| >6o16 Chain A (length=798) Species: 10090 (Mus musculus)
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VFIPVNRTPEMQEERLKLPILAEEQAIMEAVAEHPIVIVCGETGSGKTTQ
VPQFLYEAGYSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSHRVVSYQIR
YEGNVTEETRIKFMTDGVLLKEIQKDFLLLKYKVVIIDEAHERSVYTDIL
LGLLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFTTPPPVIKVES
RFPVTVHFNDDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLR
KAFLPLHVLPLYSLLAPEKQAQVFKPPPGTRLCVVATNVAETSLTIPGIK
YVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRL
YSSAVFGDFEQFPPPEITRRPVEDLILQMKALSIEKVINFPFPTPPSVEA
LVAAEELLVALGALQAQLSCPITALGRTMSTFPVAPRYAKMLALSQQHGC
LPYTIAIVAAMTVRELFEELDREKELAELKGRRARVAQMKRTWAGQGPSL
KLGDLMVLLGAVGACEYAGCSPQFCQANGLRYKAMLEIRRLRGQLTTAVN
AVCPEDPKMQPPTESQVTYLRQIMAAGLGDHLARRVQSLDPKWKNAYKTP
LLDDPVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSTVEIQWIPSLL
PSYCQFDAPLEEPAPSYCPESGQVLCHRASVFYRVGWPLPAVQVDFPEGI
DRYKYFAKFLLEGQVFRKLASFKSCLLSSPSTMLKTWARLQPRTETLLRA
LVAHKADSRDSLLAAWKKNPKYLLAEYCEWLPKAMHSDVEKNWPPTTD |
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| PDB | 6o16 Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis. |
| Resolution | 2.875 Å |
Binding residue
(original residue number in PDB) | P302 R303 R304 R330 T345 D346 G347 V348 S374 Y376 G474 Q475 S588 T613 N614 V615 S619 K635 F648 R696 P772 R803 E804 R811 Q887 N946 H960 P961 F966 K967 L969 T981 K983 Y985 |
Binding residue
(residue number reindexed from 1) | P72 R73 R74 R100 T115 D116 G117 V118 S144 Y146 G238 Q239 S263 T287 N288 V289 S293 K309 F322 R370 P433 R464 E465 R472 Q544 N595 H609 P610 F615 K616 L618 T630 K632 Y634 |
| Binding affinity | PDBbind-CN: Kd=9.83nM |
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| Enzyme Commision number |
3.6.4.13: RNA helicase. |
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