Structure of PDB 6o07 Chain A Binding Site BS01

Receptor Information
>6o07 Chain A (length=763) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDSLALKGLDLYSVGEKDDAASYVANAIRKIESASPICCHVLGIYMRNTK
EYKESIKWFTAALNNGSTNKQIYRDLATLQSQIGDFKSALVSRKKYWEAF
LGYRANWTSLAVAQDVNGERQQAINTLSQFEKLAEGKISDSEKYEHSECL
MYKNDVMYKAASDNQDKLQNVLKHLNDIEPCVFDKFGLLERKATIYMKLG
QLKDASIVYRTLIKRNPDNFKYYKLLEVSLGIQGDNKLKKALYGKLEQFY
PRCEPPKFIPLTFLQDKEELSKKLREYVLPQLKRGVPATFSNVKPLYQRR
KSKVSPLLEKIVLDYLSGLDPTQDPIPFIWTNYYLSQHFLFLKDFPKAQE
YIDAALDHTPTLVEFYILKARILKHLGLMDTAAGILEEGRQLDLQDRFIN
CKTVKYFLRANNIDKAVEVASLFTKNDDSVNGIKDLHLVEASWFIVEQAE
AYYRLYLDRKKKLDDLESLEQIANDIKENQWLVRKYKGLALKRFNAIPKF
YKQFEDDQLDFHSYCMRKGTPRAYLEMLEWGKALYTKPMYVRAMKEASKL
YFQMHDDRLKRKEAAAMNKRKETEAKSVAAYPSDQDNDVFGEKLIETSTP
MEDFATEFYNNYSMQVREDERDYILDFEFNYRIGKLALCFASLNKFAKRF
GTTSGLFGSMAIVLLHATRNDTPFDPILKKVVTKSLEKEYSENFPLNEIS
NNSFDWLNFYQEKFGKNDINGLLFLYRYRDDVPIGSSNLKEMIISSLSPL
EPHSQNEILQYYL
Ligand information
Ligand IDIHP
InChIInChI=1S/C6H18O24P6/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24)/t1-,2-,3-,4+,5-,6-
InChIKeyIMQLKJBTEOYOSI-GPIVLXJGSA-N
SMILES
SoftwareSMILES
CACTVS 3.385O[P](O)(=O)O[CH]1[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH]1O[P](O)(O)=O
ACDLabs 12.01
OpenEye OEToolkits 2.0.7		C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O
CACTVS 3.385O[P](O)(=O)O[C@@H]1[C@H](O[P](O)(O)=O)[C@H](O[P](O)(O)=O)[C@@H](O[P](O)(O)=O)[C@H](O[P](O)(O)=O)[C@H]1O[P](O)(O)=O
FormulaC6 H18 O24 P6
NameINOSITOL HEXAKISPHOSPHATE;
MYO-INOSITOL HEXAKISPHOSPHATE;
INOSITOL 1,2,3,4,5,6-HEXAKISPHOSPHATE
ChEMBLCHEMBL1233511
DrugBankDB14981
ZINCZINC000169289809
PDB chain6o07 Chain A Residue 920 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6o07 Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex.
Resolution2.702 Å
Binding residue
(original residue number in PDB)		K349 R426 K429 H430 K457 K460 Y461 R464
Binding residue
(residue number reindexed from 1)		K294 R371 K374 H375 K402 K405 Y406 R409
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004596 peptide alpha-N-acetyltransferase activity
GO:0005515 protein binding
GO:0043022 ribosome binding
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0031415 NatA complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6o07, PDBe:6o07, PDBj:6o07
PDBsum6o07
PubMed31155310
UniProtP12945|NAT1_YEAST N-terminal acetyltransferase A complex subunit NAT1 (Gene Name=NAT1)

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