Structure of PDB 6nuf Chain A Binding Site BS01

Receptor Information

>6nuf Chain A (length=360) Species: 9606 (Homo sapiens)

LSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPAN
TRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYF
TFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLD
DIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFY
SYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPN
YLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLN

Ligand information

>6nuf Chain C (length=19) Species: 9606 (Homo sapiens)

NNYLTVPADLPVITIDPAS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6nuf Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): Y288 T297 G298 F299 N327 V328 M329 N330 I331 Q333 W352 S353 F356 E359 K360
• Binding residue (residue number reindexed from 1): Y278 T287 G288 F289 N317 V318 M319 N320 I321 Q323 W342 S343 F346 E349 K350

Enzymatic activity

• Catalytic site (original residue number in PDB): D90 H92 D118 D121 R122 N150 H151 H199 R254 H281
• Catalytic site (residue number reindexed from 1): D80 H82 D108 D111 R112 N140 H141 H189 R244 H271
• Enzyme Commision number: 3.1.3.16: protein-serine/threonine phosphatase.

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity
• GO:0033192 calmodulin-dependent protein phosphatase activity

Biological Process

• GO:0097720 calcineurin-mediated signaling

External links

• PDB: RCSB:6nuf, PDBe:6nuf, PDBj:6nuf
• PDBsum: 6nuf
• PubMed: 31375679
• UniProt: Q08209|PP2BA_HUMAN Protein phosphatase 3 catalytic subunit alpha (Gene Name=PPP3CA)