Structure of PDB 6npz Chain A Binding Site BS01

Receptor Information
>6npz Chain A (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE
VAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR
ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKIT
DFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYE
MMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQR
LGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEE
FTAQMITIRRPHFPQFSYSASG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6npz Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.
Resolution2.12 Å
Binding residue
(original residue number in PDB)		G159 T160 V164 A177 H194 E234 F236 D274 K276 E278 M281 F309 C310 G311 T312 E314 F438
Binding residue
(residue number reindexed from 1)		G18 T19 V23 A36 H53 E93 F95 D133 K135 E137 M140 F168 C169 G170 T171 E173 F297
Enzymatic activity
Catalytic site (original residue number in PDB) D274 K276 N279 D292 T312
Catalytic site (residue number reindexed from 1) D133 K135 N138 D151 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6npz, PDBe:6npz, PDBj:6npz
PDBsum6npz
PubMed30078705
UniProtP31749|AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (Gene Name=AKT1)

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