Structure of PDB 6nke Chain A Binding Site BS01

Receptor Information
>6nke Chain A (length=249) Species: 273116 (Thermoplasma volcanium GSS1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTILKQMMRKLKNEKIHMTLIDPAAKSPDESAKIAKEAEMAGTDFIMVGG
STDIDERLMDQTVSAIKENTNLKVILFPGSSNMISRHADAIFFMSLLNSS
DREFIVGHQVKASKFLSLLGIEKIPMAYLVFSPGMTVGRVGKANLIDSFD
RETALSYSLAAQYMGFKLIYFEAGSGAPRPVSEDTISYVKSKINIPLIVG
GGIRDPETAMRIALAGADMIVTGSIAEKSNNVYSVLRNIIGKIKSIEIK
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain6nke Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6nke Structural studies of geranylgeranylglyceryl phosphate synthase, a prenyltransferase found in thermophilic Euryarchaeota.
Resolution1.72 Å
Binding residue
(original residue number in PDB)		Y170 E172 S175 G200 G201
Binding residue
(residue number reindexed from 1)		Y170 E172 S175 G200 G201
Annotation score2
Enzymatic activity
Enzyme Commision number 2.5.1.41: phosphoglycerol geranylgeranyltransferase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0002094 polyprenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
GO:0047294 phosphoglycerol geranylgeranyltransferase activity
Biological Process
GO:0006650 glycerophospholipid metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6nke, PDBe:6nke, PDBj:6nke
PDBsum6nke
PubMed32496216
UniProtQ97AR4|GGGPS_THEVO Geranylgeranylglyceryl phosphate synthase (Gene Name=TV0745)

[Back to BioLiP]