Structure of PDB 6nk1 Chain A Binding Site BS01

Receptor Information
>6nk1 Chain A (length=181) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGD
QDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAES
DLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRK
GFYLAFQDIGACVALLSVRVYYKKAHHHHHH
Ligand information
>6nk1 Chain C (length=14) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AWLAYPDSVPYRPK
Receptor-Ligand Complex Structure
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PDB6nk1 Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		E40 L54 M55 Q56 N57 Y65 M66 C70 R103 F108 F156 R159 V161 C188 V189
Binding residue
(residue number reindexed from 1)		E14 L28 M29 Q30 N31 Y39 M40 C44 R77 F82 F130 R133 V135 C162 V163
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:6nk1, PDBe:6nk1, PDBj:6nk1
PDBsum6nk1
PubMed31015204
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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