Structure of PDB 6nk0 Chain A Binding Site BS01
Receptor Information
>6nk0 Chain A (length=178) Species:
9606
(Homo sapiens) [
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GEVVLLDFAAAGGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDN
WLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLD
YGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFY
LAFQDIGACVALLSVRVYYKKAHHHHHH
Ligand information
>6nk0 Chain C (length=11) Species:
32630
(synthetic construct) [
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AWLAYPDSVPY
Receptor-Ligand Complex Structure
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PDB
6nk0
Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
Resolution
1.53 Å
Binding residue
(original residue number in PDB)
L54 M55 Q56 N57 Y65 M66 C70 R103 F108 F156 R159 V161 C188 V189
Binding residue
(residue number reindexed from 1)
L25 M26 Q27 N28 Y36 M37 C41 R74 F79 F127 R130 V132 C159 V160
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:6nk0
,
PDBe:6nk0
,
PDBj:6nk0
PDBsum
6nk0
PubMed
31015204
UniProt
P29317
|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)
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