Structure of PDB 6njz Chain A Binding Site BS01
Receptor Information
>6njz Chain A (length=179) Species:
9606
(Homo sapiens) [
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GEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGD
QDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAES
DLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRK
GFYLAFQDIGACVALLSVRVYYKKAHHHH
Ligand information
>6njz Chain C (length=10) Species:
32630
(synthetic construct) [
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YSAYPDSVPM
Receptor-Ligand Complex Structure
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PDB
6njz
Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
L54 M55 Q56 N57 M59 Y65 M66 C70 R103 F108 F156 R159 V161 C188 V189
Binding residue
(residue number reindexed from 1)
L28 M29 Q30 N31 M33 Y39 M40 C44 R77 F82 F130 R133 V135 C162 V163
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:6njz
,
PDBe:6njz
,
PDBj:6njz
PDBsum
6njz
PubMed
31015204
UniProt
P29317
|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)
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