Structure of PDB 6nfj Chain A Binding Site BS01

Receptor Information
>6nfj Chain A (length=844) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FSGDGRAIWSDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHG
SSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYS
TLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCF
QMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKA
HSKVWHNYNTHFRPHQKGWLSITLGSHWIEPQRSENTMDIFKCQQSMVSV
LGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGP
NNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVK
TEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRR
GLFYVDFNSKQKERKPKSSAHYYKQIIRENGESTPDVQGQFPCDFSWGVT
ESVLKPCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGQLSAVNRQA
LRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEA
FQAYAGLCFQELGDLVKLWITINEPNRLSDINDTYGAAHNLLVAHALAWR
LYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAE
PLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALN
HFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLR
WVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVR
IKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFP
Ligand information
Receptor-Ligand Complex Structure
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PDB6nfj Structures of ligand-occupied beta-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
Resolution3.19 Å
Binding residue
(original residue number in PDB)		L394 W419 F420 M435 Y643 E693 F826 F849 L850 Q851 F931 F942
Binding residue
(residue number reindexed from 1)		L318 W343 F344 M359 Y524 E574 F702 F725 L726 Q727 F807 F818
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6nfj, PDBe:6nfj, PDBj:6nfj
PDBsum6nfj
PubMed30944224
UniProtQ86Z14|KLOTB_HUMAN Beta-klotho (Gene Name=KLB)

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